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Welcome to the Topolnik Lab

Université Laval, Quebec City. Canada

Our lab conducts basic and translational neuroscience research in the areas of neural circuits, synaptic plasticity, and intracellular signalling. Our research program aims to advance understanding of the functional organization of cortical GABAergic inhibitory circuits by establishing links between different cell types, their connectivity, and network function in the context of cognitive behavior and brain circuit disorders. The projects funded by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada concentrate on different aspects of inhibitory interneuron organization (cell types, connectivity, dendritic integration and synaptic plasticity), function (activity in vivo during network oscillations and behaviour states) and dysfunction in disease (ALS and Alzheimer’s Disease).

Lab News

Congratulation to the lab for receiving a second CIHR Project Grant with a focus on dendritic integration and plasticity in interneurons.

Congratulations to Sona Amalyan, Suhel Tamboli, Ivan Lazarevich and Dimitry Topolnik for their work published in Cell Reports. Enhanced motor cortex output and disinhibition in asymptomatic female mice with C9orf72 genetic expansion.

Congratulations to Parisa Iloun for winning the PhD fellowship from the Fonds de Recherche du Québec en Santé.

Congratulations to Suhel Tamboli for a Review article published in Nature Reviews Neuroscience. The role of inhibitory circuits in hippocampal memory processing.

Congratulations to Felix Veillette for winning the NSERC Undergraduate Student Research Award.